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The results of the present study revealed that nearly half of the patients in the treatment group showed significant hearing improvement with IT administration of methylprednisolone after unsuccessful IV steroid administration, whereas none in the matched control group had similar improvement. In contrast, sex, age, affected ear, days to admission and shape of the initial audiogram, did not show any significant influence on the outcome. The present study suggests that IT administration of methylprednizolone in the middle ear is effective and safe treatment for patients with idiopathic SSHL who have failed traditional systemic steroid administration.

Although it may also be effective as 1st-line treatment, we can only recommend it for the patients who have failed traditional systemic steroid administration, because of the design of the present study. Current literature indicates the need for evidence-based, prospective randomized controlled clinical trials to test the efficacy of IT steroids as 1st line treatment.

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Secondarily, to evaluate the possible role of reproductive, lifestyle and hormonal factors in their presence. Given that E-cadherin and VEGF are expressed aberrantly during cervical carcinogenesis, their differences may reflect, at least partly, the possible treatment-induced cytological changes of the uterine cervix.

Material and method: healthy postmenopausal women aged years old attending a university menopause clinic were enrolled in this cross-sectional study. E-cadherin and VEGF immunostaining was evaluated in squamous, glandular and squamous metaplastic cells, using a semi-quantitative method rating scale: Conclusions: E-cadherin and VEGF expression seems to be associated with reproductive history, lifestyle habits, endogenous hormones and tibolone use in cervical epithelial cells from healthy postmenopausal women.

E-cadherin might participate in the molecular mechanisms underlying the role of parity as a risk factor for cervical cancer. HT and raloxifene, probably, do not exert stimulating effect on cervical epithelium, while the observed negative association between tibolone and E-cadherin immunostaining in metaplastic cells needs further study. Goodness-of-fit measures and outlier detection in latent variable models with categorical and mixed data.


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Aspergillus pathogens usually infect immunocompromised patients with lethal outcome. Conventional histological, microbiological and radiological methods used in the IA diagnosis are time-consuming and lack sensitivity and specificity. In total, 59 Aspergillus isolates were tested in this study. Four species specific primer pairs were designed to amplify the A.

The aforementioned primer sets were also tested for possible cross reactions with other clinically significant fungal, bacterial and viral taxa. Except from the A. The primer pairs specificity results indicated that the A. Rhinoviruses RVs are responsible for the majority of acute asthma and chronic obstructive pulmonary disease COPD exacerbations.

RVs infect the lower airways and induce the production of pro? The possibility that rhinoviruses may also contribute to the fibrotic component of airway remodeling has not been assessed. On the other hand, budesonide and formoterol synergize in controlling asthma and COPD exacerbations; however, their effects on virus? Therefore, we also investigated whether budesonide and formoterol synergize in suppressing RV?

Rhinovirus epithelial infection stimulated mRNA expression and release of bFGF, the latter being positively correlated with cell death under conditions promoting rhinovirus? Supernatants from infected cultures induced lung fibroblast proliferation, which was inhibited by anti? Budesonide effectively suppressed RV?

The combination of budesonide and formoterol had concentration? Combination treatment also resulted in an enhanced suppression of RV? Thus, rhinovirus infection induces bFGF release by airway epithelium, and stimulates stroma cell proliferation that may contribute to airway remodeling in asthma. Furthermore, budesonide and formoterol suppress RV?

These data further support the combined use of budesonide and formoterol in asthma and COPD and intensification of this therapy during exacerbations.

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Languages Greek English French German There is limited evidence… more. Patients and… more. Estrogens may prevent the evolution of atherosclerosis by suppressing immune… more.

Objective: The main… more. Common symptoms such… more. Common symptoms such as tinnitus, vertigo, otalgia and dizziness occur frequently in TMD patients. The present investigation was conducted in order to determine if otologic symptoms are more prevalent in TMD patients than in the normal population. We surveyed 40 patients suffering from confirmed TMD. Otologic symptoms and laboratory findings were significantly more frequent in our TMD cohort than in the general population. The aim of this study was to compare a group of TMD patients with the normal population according to the international literature in order to clarify if there is a considerable connection between TMD and neurotologic findings, and to determine if these findings are in fact prevalent in this group.

Various otogenous symptoms such as otalgia, pain around the ear area, dizziness, tinnitus and vertigo are often reported from TMD patients. The mechanism of this association is unknown. Still the best, easiest, most cost-effective way to stay in contact with customers.

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